Isocitrate Dehydrogenase (IDH)

Isocitrate Dehydrogenase (IDH) Related Products (23):

Cat. No.	Product Name	Effect	Purity

HY-18767

Ivosidenib	Inhibitor	99.85%
Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity.

HY-15734

AGI-6780	Inhibitor	99.31%
AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2^R140Q with IC₅₀ of 23±1.7 nM. AGI-6780 is less potent against IDH2^WT with IC₅₀ of 190±8.1 nM.

HY-104036

IDH-305	Inhibitor	98.75%
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC₅₀= 27 nM (IDH1^R132H), 28 nM (IDH1^R132C), 6.14 µM (IDH1^WT)).

HY-129545

DS-1001b	Inhibitor	99.71%
DS-1001b is an orally active, blood-brain permeable, potent IDH-1 (isocitrate dehydrogenase-1) mutant inhibitor. DS-1001b has antitumor activity.

HY-18767A

(R,S)-Ivosidenib	Inhibitor	98.49%
(R,S)-Ivosidenib ((R,S)-AG-120) is the less active enantiomer of Ivosidenib (AG-120).

HY-131521

Oxalomalic acid trisodium	Inhibitor
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages.

HY-112289

IDH889	Inhibitor	99.96%
IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC₅₀s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1^R132H, IDH1^R132C and IDH1^wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC₅₀ of 0.014 μM.

HY-13972

Mutant IDH1 inhibitor	Inhibitor	99.40%
Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC₅₀ of < 72 nM.

HY-112601

IDH1 Inhibitor 1	Inhibitor	99.96%
IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC₅₀s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1^R132H, IDH1^R132C, and IDH1^WT, respectively. Anticancer activity.

HY-P2993

Isocitrate dehydrogenase, Porcine heart
Isocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P)⁺ to NAD(P)H, it plays important roles in cellular metabolism.

HY-150238S

IDH1 Inhibitor 7-d₂	Inhibitor	99.93%
IDH1 Inhibitor 7-d₂ is the deuterium labeled IDH1 Inhibitor 7 (HY-150238). IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC₅₀ of less than 100 nM.

HY-41648

IDH1 Inhibitor 8	Inhibitor	≥99.0%
IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer.

HY-107977

IDH1 Inhibitor 3	Inhibitor
IDH1 Inhibitor 3 (compound 6f) is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor, with an IC₅₀ of 45 nM for IDH1^R132H.

HY-128888A

(S,S)-GSK321	Inhibitor	99.78%
(S,S)-GSK321 is a (S,S)-enantiomer of GSK321.

HY-114459

Mutant IDH1-IN-4	Inhibitor	≥99.0%
Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC₅₀ values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells.

HY-112289B

(1R)-IDH889
(1R)-IDH889 is the isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC₅₀s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1^R132H, IDH1^R132C and IDH1^wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC₅₀ of 0.014 μM.

HY-143306

IDH1 Inhibitor 5	Inhibitor
IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC₅₀s of 64.4 and 34.9 nM, respectively.

HY-156158

IDH2R140Q-IN-2	Inhibitor
IDH2^R140Q-IN-2 (compound 36) is an an orally active IDH2^R140Q inhibitor (IC₅₀: 29 nM). IDH2^R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2^R140Q (IC₅₀: 10 nM). IDH2^R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2^R140Q-IN-2 can be used for research of acute myeloid leukemia (AML).

HY-146002

IDH2R140Q-IN-1	Inhibitor
IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2^R140Q, with an IC₅₀ of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia.

HY-136686

IDH-C227	Inhibitor
IDH-C227 is a potent and selective IDH1^R132H inhibitor. IDH-C227 has anticancer effcts.

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